Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human CD72
Predicted to enable signaling receptor binding activity Predicted to be involved in cell adhesion Is integral component of plasma membrane
ABclonal Technology 647 Rabbit anti-Human CD72
Predicted to enable signaling receptor binding activity Predicted to be involved in cell adhesion Is integral component of plasma membrane
ABclonal Technology 647 Rabbit anti-Human CD172b
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes This protein was found to interact with TYROBP DAP12 a protein bearing immunoreceptor tyrosine-based activation motifs This protein was also reported to participate in the recruitment of tyrosine kinase SYK Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human PLZF
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus This protein is located in the nucleus is involved in cell cycle progression and interacts with a histone deacetylase Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) Alternate transcriptional splice variants have been characterized
ABclonal Technology APC Rabbit anti-Human CD5 mAb
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes T lymphocytes and a subset of B lymphocytes The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation Alternative splicing results in multiple transcript variants encoding different isoforms
ABclonal Technology 647 Rabbit anti-Human CD177
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration Mutations in this gene are associated with myeloproliferative diseases Over-expression of this gene has been found in patients with polycythemia rubra vera Autoantibodies against the protein may result in pulmonary transfusion reactions and it may be involved in Wegener s granulomatosis A related pseudogene which is adjacent to this gene on chromosome 19 has been identified
ABclonal Technology PE Rabbit anti-Human CD72 mAb
Predicted to enable signaling receptor binding activity Predicted to be involved in cell adhesion Is integral component of plasma membrane
ABclonal Technology 488 Rabbit anti-Human CD71
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis This receptor is required for erythropoiesis and neurologic development Multiple alternatively spliced variants have been identified
ABclonal Technology 488 Rabbit anti-Human DLL4
This gene is a homolog of the Drosophila delta gene The delta gene family encodes Notch ligands that are characterized by a DSL domain EGF repeats and a transmembrane domain
ABclonal Technology 488 Rabbit anti-Human GPRC5D
The protein encoded by this gene is a member of the G protein-coupled receptor family however the specific function of this gene has not yet been determined
ABclonal Technology 450 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology 647 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein essential for initiating blood coagulation It acts as a high-affinity receptor for factor VII forming a complex that triggers protease cascades via limited proteolysis Unlike other coagulation cofactors factor III is fully functional when expressed on cell surfaces such as on monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor during procoagulatory and proinflammatory responses Factor III is implicated in HIV-related coagulopathy and is associated with COVID-19 severity and mortality Notably congenital deficiency of this protein has not been observed Multiple transcript variants exist due to alternative splicing
ABclonal Technology PE Rabbit anti-Human CD45 mAb
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
Biotium CD66 (CEA)(C66/261), CF594 conjugate, 0.1mg/mL
This antibody recognizes proteins of 80-200 kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA positive) from pleural mesotheliomas (rarely or weakly CEA positive). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.Primary antibodies are available purified, or with a selection of fluorescent CF